Pdf preparation, characterization, and dissolution studies. Physical mixtures pms of ibuprofen were also prepared with the same carrier and in the same drugcarrier. Preparation and evaluation of fast dissolving ibuprofen. It is very slightly soluble in water and hence orally administered drug is less bioavailable. The purpose of this study was to prepare and characterize solid dispersions of the nsaid ibuprofen with. Solid dispersion, solubility enhancement, solvent evaporation technique, introduction solid dispersions sds are resulted by dispersion of drug in biologically inert matrix. The solid dispersion of ibuprofen was prepared by following methods. Pdf ddw103 development of a rapid dissolving ibuprofen. Solubility enhancement of nimesulide and ibuprofen by. Enhancement of solubility, dissolution and bioavailability of. Study of binary and ternary solid dispersion of ibuprofen for.
Methods and polymers to increase the solubility of poorly soluble drugs ladan 1akbarpour nikghalb, gurinder singh2, gaurav singh2 and kimia fazaeli kahkeshan1 1gautam college of pharmacy, bangalore, karnataka, india. Peg 6000 was melted at 5060 c and added to the ibuprofen solution and mixed thoroughly. By means of thermal analysis, we have demonstrated the total immiscibility, in solid state, of the corresponding binary mixtures. Solubility enhancement of nimesulide and ibuprofen by solid. Effect of water soluble polymers on dissolution enhancement of ibuprofen solid dispersion prepared by fusion method. Jebasingh, sachinandhan basak2 1department of pharmaceutical sciences, mohamed sathak a. Development and characterization of solid dispersion for. After the study of sem, ftir and dsc it was found that solid dispersion of ibuprofen using poloxamer 407 and peg 6000. Research article preparation and evaluation of paracetamol by solid dispersion technique d. The present study is aimed at improving the dissolution of poorly watersoluble drug, aceclofenac. Solid dispersions sds of ibuprofen ibu were prepared with four carriers. The table 1 contains the composition of solid dispersion. Introduction solid dispersion system sds has been used to improve the solubility, dissolution rate and absorption of poorly watersoluble drugs sohn and gibaldi, 1996.
To develop a novel ibuprofenloaded solid dispersion with enhanced. Preparation of solid dispersions solid dispersions of ibuprofen and peg were prepared by fusionsolvent method. Drug content of the solid dispersions was found to be between 94. Investigation of solid dispersion technique in improvement of. To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions sd were prepared in a relatively easy, simple, quick, inexpensive, and. Dispersion of ibuprofen in sorbitol showed maximum enhancement of solubility up to 75%.
The present study was aimed to enhance the solubility of poorly water soluble drug ibuprofen using solid dispersion technique and to develop sustained release tablets containing solid dispersion granules of the optimized batch. This indicated that ibuprofen as uniformly distributed in all these prepared. Solvent evaporation method solid dispersions of ibuprofen and carrier peg 6000 were prepared by ratio of 1. They can be used to increase the solubility of a drug with low aqueous solubility, thereby improving its oral bioavailability. Ibuprofen, solid dispersions, physical mixtures, hydrogenated castor oil, stearic acid, cethyl alcohol.
Physicochemical properties of the sds obtained were investigated by differential scanning calorimetry dsc, powder xray diffraction pxrd, scanning electron microscope sem, and fourier. All the physical mixtures and solid dispersions showed the presence of high drug content and low standard deviations of the results. Preparation and evaluation of ibuprofen solid dispersion. Solid dispersion as an approach for solubility and dissolution enhancement of ibuprofen and piroxicam. Hpmc, hpc, icing sugar, dextrose, mannitol and lactose. Introduction solid dispersion technique can be used to enhance the solubility, dissolution rate and absorption of several insoluble drugs 1. Solid dispersion, ibuprofen, coprecipitation, poloxamer407, dissolution. Ibuprofen is a nonsteroidal antiinflammatory drug nsaid with analgesic, antipyretic, and antiinflammatory properties methods.
Solid dispersion granules were prepared using waterbased solid dispersion and waterretained pcs with the wet granulation method and a highspeed agitation granulator. Pdf solubility and dissolution enhancement of ibuprofen by. Thus microwave technology offers a simple, efficient, shorter preparation time, solvent free promising alternative method to solid dispersion of ibuprofen with significant enhancement of the in vitro dissolution rate. Preparation of solid dispersions, and determination of drug content and percent yieldibuprofen and peg 8000 in 4. The increased dissolution rates from solid dispersions are mostly attributed to the reduction of particle size of the drug within the dispersions and increased wettability. Preparation and evaluation of ibuprofen solid dispersion tablets with improved dissolution and less sticking using porous calcium silicate. Kollidon 25, kollidon 30, kollidon va64, and kollidon cl, using a newly developed pulse combustion dryer system, hypulcon. The most frequent causes of low oral bioavailability are attributed to poor solubility and low permeability. Enhancement of solubility and dissolution characteristics of ibuprofen by solid dispersion technique article pdf available in dhaka university journal of pharmaceutical sciences 111. Solid dispersions were characterized by saturation solubility, drug content, in vitro dissolution, ftir and dsc analysis.
In this study solid dispersions sds of ibuprofen were prepared by melt dispersion technique using macrogol 4000 and macrogol 6000 as carrier. The samples were investigated for drug content, dissolution characteristics, sem, ftir and dsc analysis. Solid dispersion of ibuprofen was prepared with poloxamer 407, pvp k12, peg 4000 and peg 6000 by melt dispersion and solvent evaporation technique to improve its physicochemical properties and dissolution characteristics. The purpose of this study was to develop ibuprofen ibpolyethylene glycol peg 8000 solid dispersions sds and investigate them for in vitro dissolution and. Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol peg, talc, and pegtalc as dispersion carriers. Solid dispersions of ibuprofen were prepared by solvent evaporation technique using peg 600 and pvp k 30, as carriers in combination and individually, in various ratios. Pdf dissolution profile of ibuprofen solid dispersion. A comparative study on the effect of solution based techniques. Composition of solid dispersion formulation drug code carrier carrier. Ibuprofen solid dispersions were prepared by the solvent and fusionsolvent methods using polyethylene glycol peg, polyvinylpyrrolidone pvp, eudragit rs po, eudragit rl po. Solid dispersion technique for improving solubility of some poorly soluble drugs mogal s. Solid dispersion technique can be used to enhance the solubility. Pdf ddw103 development of a rapid dissolving ibuprofen solid. Development of novel ibuprofenloaded solid dispersion with.
Ibuprofen, urea, solid dispersions, dissolution rate. Dissolution enhancement of ibuprofen solid dispersion prepared with vinyl polymers by fusion method. Highspeed mixer abstract the aim of this study was to prepare and evaluate ibuprofen ibu. Pdf solubility and dissolution enhancement of ibuprofen by solid.
The term solid dispersion refers to a grou p of solid products consisting of at least two differe nt components, generally a hydrophilic matrix and a hydrophobic drug. Evaluation of solid dispersed particles for formulation of oral. Preparation, characterization and dissolution of solid. In order to enhance the bioavailability it is necessary. Impact assessment of different polymers on physicochemical. Saturation solubility study of solid dispersions using. Comparative study of sustainedrelease lipid microparticles. The required amount of ibuprofen was dissolved in methanol.
Enhancement of oral bioavailability and solid dispersion. Pdf on jan 10, 20, abdul wahab and others published preparation and evaluation of solid dispersions of ibuprofen using glucosamine hcl as a carrier. Research article application of box behnken design in. As can be seen, solid dispersions of ibuprofen in hydrogenated castor oil and stearic acid presented a higher percentage of particles with average size higher than m. Solid dispersion of ibuprofen containing peg 6000 in combination with poloxamer 407 at the ratio of 1. The endothermic peak of ibuprofen is of very high intensity.
Improvement of dissolution rate of ibuprofen by solid dispersion. Improved dissolution and antiinflammatory activity of ibuprofen. Solid dispersion technique for improving solubility of some. In this microwave induced solid dispersion exhibit significant improvement in solubility and dissolution rate compared to that of pure drug. Pdf effect of water soluble polymers on dissolution. Other solid dispersions containing hpmc, either kinds of. Pdf dissolution enhancement of ibuprofen solid dispersion. Reddys laboratories ltd, bachupalli, qutubullapur, rr district 500090. Pdf ibuprofen solid dispersions were prepared with the objective of solubility and dissolution improvement using peg 6000pvp k 30. Solid dispersion as an approach for solubility and. Pdf on apr 25, 2007, teofilo vasconcelos and others published ddw103 development of a rapid dissolving ibuprofen solid dispersion find, read and cite. This ratio was used to make certain that the excipient contained the ibuprofen, in order to obtain the sustained release of the ibuprofen. It indicates that the drug is uniformly dispersed in the powder formulation. Preparation of solid dispersions containing ibuprofen solid dispersions at a 1.
Dissolution profile of ibuprofen solid dispersion prepared with cellulosic polymers and sugar by fusion method. Solubility enhancement of ibuprofen by porous solid. Solid dispersions of ibuprofen with various phospholipids were prepared, and the effect of phospholipids on the in vitro dissolution and in vivo gastrointestinal toxicity of ibuprofen was evaluated. The aim of this study was to investigate the solid dispersion phase behavior of s. Prolongedrelease solid dispersions of ibuprofen japs. The solid dispersion of ibuprofen in cethyl alcohol showed a higher percentage of particles between 500 and m. Design, development and evaluation of immediate release. The saturation solubility of pure ibuprofen, various prepared ibuprofen solid.
Solid dispersion technique can be used to enhance the. Pdf on jan 10, 20, abdul wahab and others published preparation and evaluation of solid dispersions of ibuprofen using glucosamine hcl as a carrier find, read and cite all the research you. In vitro release of ibuprofen and ibuprofen from solid dispersions time ibuprofen release % ibuprofen ibuprofen. Enhancement of solubility and dissolution characteristics of. We prepared solid dispersions sds of ibuprofen ibu with kollicoat ir as the carrier using a newly developed pulse combustion dryer systemhypulcon. Most phospholipids improved the dissolution of ibuprofen. Ternary solid dispersions were prepared by hotmelt granulation in which the drug, ibuprofen was dispersed in a molten dispersion carrier and coated onto an adsorbent. Enhanced dissolution of ibuprofen using solid dispersion with. Though ibuprofen is absorbed rapidly and bound avidly to protein, it is not.
Solid dispersions of ibuprofen prepared by the freeze drying method provided the highest dissolution rate and per centage of drug dissolved. Pdf preparation and evaluation of solid dispersions of ibuprofen. The different solid dispersion methods were studied using peg 6000 as carrier. The aim of this study was to prepare and evaluate ibuprofen ibu solid dispersion tablets with improved dissolution and less sticking using porous calcium silicate pcs. The xrd study of the porous solid dispersion showed peaks for pure ibuprofen and pvp k30, indicating that there was no chemical interaction between the drug and the carrier. In vivo in vitro evaluation of solid dispersion containing. Solid dispersions of nimesulide with peg6000 enhanced the solubility of nimesulide by more than %. Types of solid dispersion as mentioned by dhirendra et al. Ibuprofen is a nonsteroidal antiinflammatory drug with poor water solubility. Pdf solubility and dissolution enhancement of ibuprofen.
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